What if the fall of Constantinople had gone differently?

Ottoman cannon breach the walls; the eastern land routes to Asia now run through one gatekeeper.

If it had gone differently: The Mediterranean spice routes stay open and cheap; no one in Iberia is desperate enough to gamble on the open ocean.

1. 1492Columbus reaches the Americas, The Atlantic stays a barrier for generations; Europe's empires grow east, not west.
2. 1600The chartered East India companies, European trade with Asia stays a matter of small merchant convoys; no company-states, no gunboat empires.